高血压与维生素d

高血压与维生素d内容摘要：

en Personyears 2207 2317 335 cases 58 60 11 Multivariable RR (95% CI) (reference) ( to ) ( to ) Measured Plasma 25(OH)D and 4Year Multivariable Adjusted Relative Risk of Incident Hypertension in Men and Wom n Multivariable models adjusted for age ,BMI,physical activity(all as continuous variables),as well as race, and(in women) menopausal status. 613 Men from Health Professionals39。 Followup Study and 1198 women from the Nurses39。 Health Study Metaanalysis of data on allcause mortality in 18 randomized controlled trials (including WHI) with vitamin D Supplementation 25OH D Levels and Myocardial Infarction Health Professionals Followup Sthdy Giovanucci et al Arch Int Med 2020 Vitamin D and subclinical atherosclerosis • Low 25(OH)D levels have been shown to be associated with: Peripheral arterial disease (ABI＜ ) Melamed ML... Michos ED et al. ATVB 2020 Teis JP, Michos ED et al. Am J Clin Nutr 2020 Increased carotid intimal medial thickness Targher G. Clin Endocrinol. 2020 Reis JP ...Michos ED et al. Atheroscierosis 2020 Incident coronary artery calcification de Boer IH...Michos ED et al. J Ain Soc Nephrol 2020 • Findings are indeperndent of traditional CVD risk factors Increased risk of allcause mortality for those at lower serum 25(OH)D levels: NHANESⅢ linked mortality study *adjusted for age, sex, race/ethnicity and season Metamed ML. Michos ED, et al. Arch Intern Med 2020。 158:16291637. Biphasic responsesuggests an optimal range where both deficiency and excess cause CVD harm Optimal D status Zittermann A Curr Opin Lipidol 2020 Feh。 18(1):416 Vitamin D and calcium supplementation for the prevention of CVD events:RCT Metaanalysis **For Vitamin D supplements alone: trend for benefit Slight (nonsignificant) reduction in CVD risk with moderate doses(~1000 IU/d) Pooled RR , 95% CI Wang L. et al. Ann Intern Med 2020。 152:315323 Vitamin。