chapter38macrolides,lincomycinsandpolymycins内容摘要:

Liver toxicity  Cardiotoxicity Erythromycin  Erythromycin lactobionate(乳糖酸红霉素)  erythromycin estolate(无味红霉素 )  erythromycin stearate(硬脂酸红霉素)  erythromycin ethylsuccinate(琥乙红霉素, 利君沙 ) New macrolides antibiotics  Advantage :  Broader spectrum, higher activity  Orally effective  High blood concentration  Longer t 1/2  Less toxicity  Mainly used in respiratory tract infection Clarithromycin(甲红霉素 ,克拉霉素)  Has the strongest activity on Grampositive bacteria, legionella pneumophila, chlamydia pneumoniae and  Good pharmacokiic property  Low toxicity Azithromycin (阿齐霉素 ,丽珠奇乐)  Has the strongest activity against mycoplasma pneumoniae(肺炎支原体)  More effective on Gramnegative bacteria  Well tolerated  T1/2 :35~48h once daily  Mainly used in respitory tract infection Roxithromycin (罗红霉素,严迪)  1987 France  The highest blood concentration。
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