receptor-mediatedendocytosis受体介导的内吞作用

receptor-mediatedendocytosis受体介导的内吞作用内容摘要：

本生理或生化缺陷知之甚少。 What is FH? What Causes FH? How is FH Inherited? What is FH? • Familial Hypercholesterolemia (FH) is an inherited disorder that causes very high cholesterol levels and greatly increases the chance of having a heart attack early in life. Heart attacks usually occur in men when they are 4055 years old and in women when they are 5065 years old. Unfortunately, they can sometimes occur when people are in their midtwenties. The first case of FH was described over 100 years ago and the characteristics of FH passing from generation to generation was understood in the late 193039。 s. Actual geic proof was discovered in the 196039。 s and 197039。 s. What Causes FH? Cholesterol is removed from the blood by the liver using Low Density Lipoprotein (LDL) receptors. Each person has two genes that are responsible for making the LDL receptors: one received from the father and one received from the mother. In a person with FH, an abnormal gene was passed on from one parent who has FH and a normal gene was passed on from the other parent. Therefore, half of the LDL receptors are absent or do not work properly and the other half are normal. Because half of the receptors do not remove the cholesterol normally, cholesterol levels increase in the blood. This results in damage to blood vessels, blockage of arteries and heart attacks at an early age. How。