感染性心内膜炎进展及指南内容摘要:

3 mg/kg per 24 h IV/IM in 1 dose 2 weeks for native valve 6 weeks for prosthetic OR Vanycin 30 mg/kg per 24 h in 2 equal doses 4 weeks for native valve to maximum of 2 g/24 h 6 weeks for prosthetic 22 抗微生物治疗  营养变异性链球菌( NVS)及青霉素高度耐药者:万古 6周 +庆大 6周  肺炎链球菌:青霉素 4周或头孢曲松 4周  耐青霉素者:头孢噻肟 4周或万古 4周或头孢曲松 +万古 4周 23 肠球菌治疗方案(一)  Regimen Dosage and route Duration   Susceptible to penicillin,gentamicin,and vanycin  Ampicillin sodium 12g/24 h IV in 6 doses 4~6 weeks  OR  Penicillin G 1830million U/24h either continuously or 6 doses 4~6 weeks  PLUS  Gentamicin 3 mg/kg per 24h IV/IM in 3 equal doses 4~6 weeks  OR  Vanycin 30 mg/kg per 24h IV in 2 equally divided doses 6 weeks  PLUS  Gentamicin 3mg/kg per 24h IV/IM in 3 equal doses 6 weeks  Susceptible to penicillin, streptomycin, vanycin, but resistant to gentamicin  Amipicillin sodium 12 g/24h IV in 6 doses 4~6 weeks  OR  Penicillin G 1830 million U/24h either continuously or 6 doses 4~6 weeks  PLUS  Streptomycin sulfate 15mg/kg per 24h IV/IM in 2 equal doses 4~6 weeks  OR  Vanycin 30mg/kg per 24h IV in 2 equally divided doses 6 weeks  PLUS  Streptomycin sulfate 15mg/kg per 24h IV/IM in 2 equal doses 6 weeks 24 肠球菌治疗方案(二)  Regimen Dosage and route Duration  Susceptible to aminoglycosides and vanycin but resistant to penicillin  Betalactamase producing strain  Ampicillinsulbactam(舒巴坦 ) 12g/24h IV in 4 doses 6 weeks  PLUS  Gentamicin 3mg/kg per 24h IV/IM in 3 equal doses 6 weeks  OR  Vanycin 30mg/kg per 24h IV in 2 equally divided doses 6 weeks  PLUS  Gentamicin 3mg/kg per 24h IV/IM in 3 equal doses 6 weeks  Intrinsic penicillin resistance  Vanycin 30mg/kg per 24h IV in 2 equally divided doses 6 weeks  PLUS  Gentamicin 3mg/kg per 24h IV/IM in 3 equal doses 6 weeks   Resistant to penicillin, aminoglycosides, and vanvomycin  (屎肠球菌)  Linezolid(利钠唑胺 ) 1200mg/24h IV/po in 2 equal doses ≥8weeks  (粪肠球菌)  Ceftriaxone sodium 2g/24h IV/IM in 1 doses ≥8weeks  PLUS  Ampicillin sodium 12g/24h IV in 6 doses ≥8weeks 25 葡萄球菌 IE抗菌素应用 TABLE 12. Oerview of therapy for endocarditis caused by staphylococcus Regimen Dosage and route Duration Methicillinsusceptible anisms(native valves) Nafcillin(新青 Ⅲ ) or oxacillin 12g/24h IV in 46 doses 6 weeks With option of gentamicin Gentamicin 3mg/kg per 24h IV/IM in 2 or 3 dose。
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