cervicalcancerhpv

cervicalcancerhpv内容摘要：

een annually with regular Paps or every 2 years with liquidbased tests • After three normal tests, can go to every three years • Stop at 6570 years with history of negative tests • Still need annual checkups Cervical Cytology Screening. ACOG Practice Bulletin No. 45. 2020。 102:41727. 17 NEW! The HPV Vaccine Gardasil 174。 (Merck) • Protects against types 16, 18, 6, 11 • FDA approved for use in females 926 years of age • Prevents HPV infection。 doesn’t treat existing infection • Viruslike particles (VLP) • Highly effective • Safe, few serious adverse side effects • Requires 3 injections • Expensive ($360 + administrative fees) Smith, RA et al. Cancer. 2020。 53(1): 2743. 18 HPV Vaccine ACOG Remendations VACCINATE all females 926 years old, regardless of sexual activity • Less potential benefit with increasing age amp。 number of sexual partners Special populations – vaccine less effective • Previous abnormal Pap tests or genital warts • Immunopromised Continue screening with Pap tests! Human Papillomavirus Vaccination. ACOG Committee Opinion No. 344. 2020。 108: 699705. 19 NOT CURRENTLY RECOMMENDED (Awaiting more evidence) Continue screening with Pap tests! • Women over age 26 • Pregnant women – If vaccine started before pregnancy, give remaining dose(s) postpartum • Breastfeeding women • Men HPV Vaccine ACOG Remendations Human Papillomavirus Vaccination. ACOG Committee Opinion No. 344. 2020。 108: 699705. 20 HPV Vaccine Important Considerations Continue screening with Pap tests! • Vaccine is most effective before first sexual intercourse – less effective in sexually active women • HPV testing before vaccine not remended • Vaccine is not a treatment for current HPV infection, genital warts, or precancer Human Papillomavirus Vaccination. ACOG Committee Opinion No. 344. 2020。 108: 699705. 21 HPV Vaccine FAQ • Vaccine will not cause HPV – Viruslike particle vaccine (not live virus) • HPV vaccines appear to be very safe – Few major adverse events, but limited data • Most side effects are minor – Injection site reaction • Potentially effective in preventing cervical cancer (and other HPVrelated cancers) – BUT not all cancercausing HPV types are covered by the vaccine Continue screening with Pap tests! Human Papillomavirus Vaccination. ACOG Committee Opinion No. 344. 2020。 108: 699705. 22 References Advisory Commi。